Madre de Dios Region in Peru:
Madre de Dios is a region in southeastern Peru, bordering Brazil, Bolivia and the Peruvian regions of Puno, Cusco and Ucayali. Its capital is the city of Puerto Maldonado. The name of the region is a very common Spanish language designation for the Virgin Mary, literally meaning Mother of God.

Geography:
The region is almost entirely low-lying Amazonian rainforest. The climate is warm and damp, with average temperatures around 26 °C (79 °F) [max.: 34 °C (93 °F), min.: 21 °C (70 °F)]. The rainy season is from December to March, when torrential rainfall causes rivers to swell and often burst their banks. Annual precipitation can be as much as 3 metres (9.8 ft).
The North-Western boundary with the Cusco Region is known as the Isthmus of Fitzcarrald, a series of small and low mountains that separate the Madre de Dios River and the Urubamba/Ucayali River basins.
Notable rivers in the Madre de Dios River watershed are:
Inambari River
Tambopata River
Manu River
Tahuamanu River
Las Piedras River, also known as Tacuatimanu River
Heath River
Acre River
Los Amigos River
Due to the vast size of the area and its low population density, rivers provide the best way of getting from one town to another. Human activity is invariably confined to riverbanks. A number of explorers have searched for the lost city of Paititi in the jungle within the region
The only important highway is between the city of Puerto Maldonado and Cusco, 510 kilometres (320 mi) away in the Cusco Region. However, it is part of the new-built Interoceanic Road between the Pacific & Atlantic Oceans, passing by the border town of Iñapari on the Acre river and flights between Cusco and Puerto Maldonado remain the most common and quicker method of transport between the two. From Puerto Maldonado there is a road to the mining town of Laberinto ("Labyrinth", about 55 kilometres (34 mi) long). A second road is between the village of Cusco and Itahuania (into the Manu National Park). It is a roughly 350 kilometres (220 mi) long single track road that is hard to pass in the rainy season. It also has a dirt road towards the native community of Infierno ('Hell') where the last Ese'ejas (or 'Guarayos') are still living, with their famous chief Agustín Shapaja, who led the famous expedition to the Candamo and was featured in the documentary "El Candamo, la Ultima Tierra sin Hombres (The Candamo, The Last Land without Men).